Lane Strathearn, MBBS FRACP PhD

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors.

Follow this format for each person. DO NOT EXCEED FIVE PAGES.

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

A. Personal Statement

I am a tenured professor of pediatrics at the University of Iowa and Division Director for Developmental and Behavioral Pediatrics, and hold an Endowed Chair for Pediatric Neurodevelopment. I have recently been appointed as the physician director of the Center for Disabilities and Development (CDD) at the University of Iowa Children's Hospital, which has been designated as a University Center for Excellence on Developmental Disabilities Education, Research and Service (UCEDD) since 1972. I am co-director for both the UCEDD and the LEND program (Leadership Education in Neurodevelopmental and related Disabilities), which provides long-term, graduate level interdisciplinary training and service, and has been continuously funded for over 20 years. My training as a developmental pediatrician, a child maltreatment specialist, and a neuroscientist has resulted in a broad perspective on the interactive effects of genes and environment on childhood neurodevelopment. This perspective and expertise will be utilized extensively in this research project. I have a proven track record of NIH funding, interdisciplinary collaboration, and leadership, with 2 current R01 grants including a competitive renewal for which I am the corresponding MPI in a multi-site study. My experimental work has included epidemiological and longitudinal research of extreme prematurity and cognitive/emotional development, randomized controlled intervention trials of intranasal oxytocin in autism and parenting, and functional MRI studies exploring the neural basis of parent-infant attachment.

My research career has consistently focused on the translation of basic science to inform clinical practice. I have drawn upon animal models of infant development and parenting behavior to test novel hypotheses using functional MRI and behavioral phenotyping, then expanding to explore high-risk populations, such as prenatally substance-abusing mothers and mothers with unresolved childhood trauma or depression.

B. Positions and Honors

Positions and Employment

Other Experience and Professional Memberships

Honors

C. Contribution to Science (Selected publications)

1. Kim S, Kwok S, Mayes LC, Potenza MN, Rutherford HJ, Strathearn L. Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways. Annals of the New York Academy of Sciences. Forthcoming;

2. Kim S, Fonagy P, Allen J, Martinez S, Iyengar U, Strathearn L. Mothers who are securely attached in pregnancy show more attuned infant mirroring 7 months postpartum. Infant Behav Dev. 2014 Nov;37(4):491-504. PubMed PMID: 25020112; PubMed Central PMCID: PMC4301602.

3. Kim S, Fonagy P, Koos O, Dorsett K, Strathearn L. Maternal oxytocin response predicts mother-to-infant gaze. Brain Res. 2014 Sep 11;1580:133-42. PubMed PMID: 24184574; PubMed Central PMCID: PMC4286383.

4. Sharp C, Kim S, Herman L, Pane H, Reuter T, Strathearn L. Major depression in mothers predicts reduced ventral striatum activation in adolescent female offspring with and without depression. J Abnorm Psychol. 2014 May;123(2):298-309. PubMed PMID: 24886004.

5. Kim S, Fonagy P, Allen J, Strathearn L. Mothers' unresolved trauma blunts amygdala response to infant distress. Soc Neurosci. 2014;9(4):352-63. PubMed PMID: 24635646; PubMed Central PMCID: PMC4260525.

6. Iyengar U, Kim S, Martinez Mills R, Alati R, Strathearn L, Najman JM. Alcohol and tobacco use among maltreated and non-maltreated adolescents in a birth cohort. Addiction. 2014 Apr;109(4):672-80. PubMed PMID: 24325599; PubMed Central PMCID: PMC4140564.

7. Mills R, Scott J, Alati R, O'Callaghan M, Najman JM, Strathearn L. Child maltreatment and adolescent mental health problems in a large birth cohort. Child Abuse Negl. 2013 May;37(5):292-302. PubMed PMID: 23380430; PubMed Central PMCID: PMC3918944.

8. Strathearn L, Iyengar U, Fonagy P, Kim S. Maternal oxytocin response during mother-infant interaction: associations with adult temperament. Horm Behav. 2012 Mar;61(3):429-35. PubMed PMID: 22306668; PubMed Central PMCID: PMC3358225.

9. Strathearn L. Maternal neglect: oxytocin, dopamine and the neurobiology of attachment. J Neuroendocrinol. 2011 Nov;23(11):1054-65. PubMed PMID: 21951160; PubMed Central PMCID: PMC3319675.

10. Mills R, Alati R, O'Callaghan M, Najman JM, Williams GM, Bor W, Strathearn L. Child abuse and neglect and cognitive function at 14 years of age: findings from a birth cohort. Pediatrics. 2011 Jan;127(1):4-10. PubMed PMID: 21135010.

11. Strathearn L, Fonagy P, Amico J, Montague PR. Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology. 2009 Dec;34(13):2655-66. PubMed PMID: 19710635; PubMed Central PMCID: PMC3041266.

12. Strathearn L, Mamun AA, Najman JM, O'Callaghan MJ. Does breastfeeding protect against substantiated child abuse and neglect? A 15-year cohort study. Pediatrics. 2009 Feb;123(2):483-93. PubMed PMID: 19171613 ; PubMed Central PMCID: PMC2650825.

13. Strathearn L, Li J, Fonagy P, Montague PR. What's in a smile? Maternal brain responses to infant facial cues. Pediatrics. 2008 Jul;122(1):40-51. PubMed PMID: 18595985; PubMed Central PMCID: PMC2597649.

14. Strathearn L, Gray PH, O'Callaghan MJ, Wood DO. Childhood neglect and cognitive development in extremely low birth weight infants: a prospective study. Pediatrics. 2001 Jul;108(1):142-51. PubMed PMID: 11433067.

Complete List of Published Work in My Bibliography:
http://bit.ly/1TAti5V

D. Research Support and/or Scholastic Performance

Ongoing Research Support

R01 DA026437-07

MAYES, LINDA Carol (PI)

04/01/09-01/31/20

Oxytocin and Brain Reward and Stress Responses to Infant Cues in Addicted Mothers

Role: PI

R03 HD080998-02

Strathearn, Lane  (PI)

04/01/15-03/31/17

Paternal Brain Responses to Infant Face Cues: Effects of Intranasal Oxytocin

Role: PI