Dr. Greg Siegle, from the University of Pittsburgh, will present a neuroscience-based framework for understanding reactions to emotional and sensory stimuli in autism that can seem very strong or almost absent, and how the same individuals may vary from one to the other type of reactivity. To support this framework, Dr. Siegle will work to integrate individuals’ neuroimaging data and their narratives, which autistic participants have said they want to have heard and understood by others. Dr. Siegle will relate these data to outcomes in a neuroimaging clinical trial of technologies to address dissociation.