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Product

LEND: Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss and survival in children with cancer: results from the childrens oncology group ACCL0431 randomized cohort trial.

Center:

OR-Oregon Institute on Development & Disability, UCEDD/LEND

Fiscal Year:

2017

Contact Information:

Kristin Knight
[email protected]
503-494-2061

Product Description:

Phase 3 randomized study to assess sodium thiosulfate (STS) for prevention of cisplatin-induced hearing loss in children and adolescents. Children were randomized to receive standard chemotherapy versus standard chemotherapy with delayed STS. Hearing was measured using standard audiometry and ototoxicity was determined using the American Speech-Language-Hearing Association Ototoxicity Criteria. Adjusted for stratification variables, the likelihood of hearing loss was significantly lower in the sodium thiosulfate group compared with the control group (odds ratio 031, 95% CI 013073; p=00036).

Keyword(s):

cisplatin, ototoxicity, hearing loss, children, cancer

Product/Publication Type(s):

Peer-reviewed publications in scholarly journals Published/In Press

Target Audience:

Professionals, Policymakers

Alternative Format:

To Obtain Copies (URL or Email):

[email protected]

COVID-19 Related Data:

N/A

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