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Product

Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma

Center:

NE-Munroe-Meyer Institute of Genetics & Rehabilitation, UCEDD/LEND

Fiscal Year:

2022

Contact Information:

Karoly Mirnics
[email protected]
402-559-6430

Product Description:

Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models. Cholesterol is one of the critical metabolites supporting PC, synthesized or acquired by PC cells. Nevertheless, the significance of the de novo cholesterol synthesis pathway has been controversial in PC, indicating the need to reassess this pathway in PC.

Keyword(s):

PCAC (pancreatic ductal adenocarcinoma), Free cholesterol, Dhcr24, Dhcr7, Sterol analysis

Product/Publication Type(s):

Peer-reviewed publications in scholarly journals Published/In Press

Target Audience:

Professionals, Policymakers, Students

Alternative Format:

Visual Format or Large Print, Electronic (disc, CD, 508 compliant web posting)

To Obtain Copies (URL or Email):

PMID: 35050168

COVID-19 Related Data:

N/A