Efficacy of Tricyclic Antidepressant therapy in Adults with Cyclic Vomiting Syndrome: A Two
Product Description:
Abstract: Aims:
To investigate the effects of prolonged tricyclic antidepressants (TCA) therapy on the frequency and
duration of episodes of cyclic vomiting syndrome (CVS) in adults as well as the global assessment of
clinical improvement and the number of emergency department (ED) visits and/ or hospitalizations.
Method:
An open labeled study was conducted in adult CVS patients treated with a TCA and followed for up to 2
years (yrs). Demographic data, TCA dosage, duration and frequency of CVS episodes, ED visits and
hospitalizations at baseline and during TCA therapy were recorded and patients were monitored for
any adverse events.
Results: 46 patients initially met the inclusion criteria and 41 patients (22 male), mean age 35 yrs
(range 18-63) on TCA were able to be followed for 1 yr and 23 were evaluated for 2 yrs. Mean age of
onset of CVS symptoms was 26 yrs (range 10-52) and mean age for making the diagnosis of CVS was 32
yrs (range 15-63). The frequency and duration of an episode and ED visits related to CVS were all
significantly reduced after both the 1st and 2nd yr of TCA therapy (p<0.05). 88% reported an
improved clinical status by subjective global assessment. Mild side effects were reported in 34% not
necessitating stoppage of the TCA.
Conclusions:
Long-term TCA therapy significantly reduces the frequency and duration of CVS episodes, ED visits &
hospitalizations (p<0.05), and improves overall clinical well being providing evidence that they are
effective therapy for adult CVS.
Product/Publication Type(s):
Peer-reviewed publications in scholarly journals Published/In Press
Target Audience:
Consumers/Families, Professionals, Students
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