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Product

Who are the nonresponders to standard treatment with tricyclic antidepressant agents for cyclic vomiting syndrome in adults?

Center:

KS-Schiefelbusch Institute for Life Span Studies, UCEDD/LEND

Fiscal Year:

2011

Contact Information:

Teri Lavenbarg
[email protected]
913-588-0698

Product Description:

RESULTS: The nonresponders were receiving TCAs at an average dose of 90 mg/day compared to a mean dose of 85 mg/day in responders. Compared with the responders, the nonresponders were significantly more likely to have a history of migraine (P < 0.05); co-existing psychological disorders (P < 0.05); chronic marijuana use (P < 0.05) and reliance on narcotics for pain control between cyclic vomiting syndrome episodes (P < 0.05). CONCLUSIONS:(1) Nonresponse to standard therapy in adult cyclic vomiting syndrome patients occurs in approximately 13% and is not explained by under dosing with TCA therapy. (2) The main risk factors for nonresponse are: co-existing migraine headache, psychiatric disorder, chronic narcotic and marijuana use, which should be addressed aggressively when symptom exacerbations continue during attempts to induce remission in cyclic vomiting syndrome with high-dose TCA therapy. PMID: 19817722 [PubMed - indexed for MEDLINE]

Keyword(s):

Vomiting/drug therapy, Antidepressive Agents, Tricyclic/adverse effects, Dose-Response Relationship, Drug, Gastric Emptying/drug effects*, Severity of Illness Index

Product/Publication Type(s):

Peer-reviewed publications in scholarly journals Published/In Press

Target Audience:

Consumers/Families, Professionals, Students

Alternative Format:

To Obtain Copies (URL or Email):

http://www.ncbi.nlm.nih.gov.proxy.kumc.edu:2048/pubmed/1981

COVID-19 Related Data:

N/A

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