Who are the nonresponders to standard treatment with tricyclic antidepressant agents for cyclic vomiting syndrome in adults?

2011

Teri Lavenbarg
[email protected]
913-588-0698

RESULTS: Forty-six patients initially met the inclusion criteria and 41 patients (22 male) with mean age of 35 years (range: 18 to 63 y) on TCA were able to be followed for 1 year and 23 were evaluated for 2 years. Mean age of onset of CVS symptoms was 26 years (range: 10 to 52 y) and mean age for making the diagnosis of CVS was 32 years (range: 15 to 63 y). The frequency and duration of an episode and ED visits related to CVS were all significantly reduced after both the first and second year of TCA therapy (P<0.05). Eighty-eight percent reported an improved clinical status by subjective global assessment. Mild side effects were reported in 34% not necessitating stoppage of the TCA. CONCLUSIONS: Long-term TCA therapy significantly reduces the frequency and duration of CVS episodes, ED visits, and hospitalizations (P<0.05), and improves overall clinical well-being providing evidence that they are effective therapy for adult CVS. PMID: 20027010 [PubMed - indexed for MEDLINE]

Vomiting/drug therapy, Antidepressive Agents, Tricyclic/adverse effects, Dose-Response Relationship, Drug, Treatment Outcome, Severity of Illness Index

Peer-reviewed publications in scholarly journals Published/In Press

Consumers/Families, Professionals, Students

http://www.ncbi.nlm.nih.gov.proxy.kumc.edu:2048/pubmed/20027010

N/A