Autonomic nerve function in adult patients with cyclic vomiting syndrome.

2012

Teri Lavenbarg
[email protected]
913-588-0698

KEY RESULTS: Twenty-two adult (18 female), mean age 35  11 (range 19-61 years), who met Rome III criteria for CVS were included. History of migraine headache was reported in three patients. Five (23%) had pediatric onset. Of 21 patients who completed the test, nine patients had 21 abnormalities detected in their autonomic nerve testing profile and the remaining 12 had normal autonomic function results. Orthostatic tachycardia was observed in two (mean heart rate increase 39 beats min(-1)) and a decline in blood pressure (BP) in three patients (mean BP drop 30/14 mmHg). Parasympathetic abnormalities were elicited in six patients with an abnormal response to deep breathing and E/I index <1.25. Sympathetic nerve dysfunction was reported in seven patients with absent sympathetic skin response in the foot and/or hand. Twelve (57%) of CVS group had rapid GET (<50% retention at 1 h). The frequency of abnormal autonomic nerve function was not significantly higher in rapid GET subgroup.

Vomiting/drug therapy, Antidepressive Agents, Tricyclic/adverse effects, Autonomic nerve function, Gastric Emptying/drug effects*, Severity of Illness Index

Peer-reviewed publications in scholarly journals Published/In Press

Consumers/Families, Professionals, Students

http://www.ncbi.nlm.nih.gov.proxy.kumc.edu:2048/pubmed/1981

N/A