Increased midgestational IFN-y, IL-4 and IL-5 in women bearing a child with autism: A case study
Product Description:
Abstract Background Immune anomalies have been documented in individuals with autism
spectrum disorders (ASDs) and their family members. It is unknown whether the maternal
immune profile during pregnancy is associated with the risk of bearing a child with ASD or other
neurodevelopmental disorders. Methods Using Luminex technology, levels of 17 cytokines and
chemokines were measured in banked serum collected from women at 15 to 19 weeks of gestation
who gave birth to a child ultimately diagnosed with (1) ASD (n = 84), (2) a developmental delay
(DD) but not autism (n = 49) or (3) no known developmental disability (general population (GP); n =
159). ASD and DD risk associated with maternal cytokine and chemokine levels was estimated by
using multivariable logistic regression analysis. Results Elevated concentrations of IFN-γ,
IL-4 and IL-5 in midgestation maternal serum were significantly associated with a 50% increased
risk of ASD, regardless of ASD onset type and the presence of in
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Peer-reviewed publications in scholarly journals Published/In Press
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