Association of Language Impairment with Language, Reading, and ADHD Candidate Genes

2014

Kellie Ellerbusch
[email protected]
402-559-4892

Specific language impairment is a significant developmental disorder in language acquisition occurring in about 7% of 6-year-olds in the US. Estimates of heritability vary based on the severity, with heritabilities greater than 0.5 for children who had been seen by a speech pathologist. The current study expands the coverage of these and additional genes, with concentration on SNPs in regulatory regions. We genotyped 422 SNPs in 23 candidate genes in 293 people from 62 nuclear families with a proband with SLI. Probands were between 3 and 12 years old and were ascertained through school-based speech pathologists, with diagnosis confirmed with standardized testing appropriate for the child's age. Their siblings between ages 2 and 17 were also recruited and tested. All children were given an additional battery of 9 tests covering reading and language abilities. Quantitative association analysis was done with the PBAT program implemented by SVS (Golden Helix) testing the hypothesis of asso

Conference presentations and posters presented

Professionals, Students

Electronic (disc, CD, 508 compliant web posting)

[email protected]

N/A