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Product

Cytogenetic studies in myelodysplastic syndromes among children and young adults

Center:

NE-Munroe-Meyer Institute of Genetics & Rehabilitation, UCEDD/LEND

Fiscal Year:

2014

Contact Information:

Kellie Ellerbusch
[email protected]
402-559-4892

Product Description:

Myelodysplastic syndromes (MDSs) are primarily bone marrow disorders of adults and are rare among children and young adults with an estimated account of 1-4 cases per million children per year. Characteristic genetic abnormalities of monosomy 5/deletion of 5q (-5/del 5q), monosomy 7/deletion of 7q (-7/del 7q), gain of chromosome 8 (+8), and deletion of 20q (del 20q) common in adult MDS are determined by cytogenetic and fluorescence in situ hybridization (FISH) techniques. These abnormalities are exhibited at different frequencies in childhood MDS cases and have a distinct prognostic impact. Conventional cytogenetics and FISH allows for an efficient and rapid detection of MDS-related abnormalities which helps in accurate diagnosis, facilitates therapeutic stratification, and is a useful prognostic tool for younger MDS patients.

Keyword(s):

Myelodysplastic syndromes, Child, diagnostics

Product/Publication Type(s):

Conference presentations and posters presented

Target Audience:

Professionals

Alternative Format:

Electronic (disc, CD, 508 compliant web posting)

To Obtain Copies (URL or Email):

[email protected]

COVID-19 Related Data:

N/A