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Kansas Intellectual and Developmental Disabilities Research Center

University of Kansas - Lawrence
Life Span Institute
1000 Sunnyside Ave
Lawrence, KS, 66045
785-864-4295

The mission of the Kansas Intellectual and Developmental Disabilities Research Center is to support high quality basic and applied research relevant to the causes and prevention of intellectual and developmental disabilities. We also support research aimed at the prevention and remediation of some of the many secondary conditions associated with intellectual and developmental disabilities, such as difficulty in language acquisition and behavior problems. For more than four decades KIDDRC, in partnership with the Eunice K. Shriver National Institute of Child Health and Human Development and other federal agencies, has played a major role in generating effective behavioral interventions aimed at the causes, prevention, and treatment for intellectual and related developmental disabilities, and in delineating basic knowledge of the underlying biology of typical and atypical development. We have accomplished this by uniting researchers and clinicians in a common effort at three critical sites within the state of Kansas: the University of Kansas in Lawrence, Juniper Gardens Children's Project; and the University of Kansas Medical Center in Kansas City with a total of 119,000 square feet of dedicated research space across the three sites, with more than half constructed since 2007. The areas of language and communication disorders (Theme 1), risk, intervention and prevention (Theme 2), neurobiology of IDD (Theme 3) and biology of early development (Theme 4) are the primary research themes. Each theme arose as a result of genuine research strengths and grassroots collaborations.

CORE(s)

Core values are the internal compass of fundamental principles that drive the work of IDDRCs.

URL: http://kiddrc.kumc.edu/coreb.html

Keywords Biobehavioral measurement; behavioral testing; rodent complex behavior and learning; rodent SensoriMotor testing

Services

Consultation
Consult with investigators about problems relevant to research measurement; suggest solutions, and direct investigators to appropriate resources.

Instrument Design and Fabrication
Devise and construct new and innovative instrumentation that addresses currently unsolved problems in areas of biobehavioral measurement.

Behavioral Testing
Provide facilities for rodent Complex Behavior and Learning; provide facilities for rodent SensoriMotor Testing; behavioral instrumentation design and fabrication. Perform behavioral testing services for IDDRC investigators as requested.

ImmunoAssay Services
Provide ImmunoAssay services of IDD related markers in biological samples.

Small Animal Surgical Services
Provide surgical services to generate IDD models in small rodent species as requested.

Software Development
Devise and modify software applications to enable KIDDRC investigators to achieve better measurements in biobehavioral experiments.

Education
Inform KIDDRC investigators regarding new measurement approaches and technologies; train them to use new instrumentation; educate them as to how best to obtain critical measurement data.

Maintenance and Repair
Maintaining and repair modern laboratory instrumentation.



URL: http://kiddrc.kumc.edu/corea.html

Keywords Administration, public information, scientific leadership

Description

Scientific Leadership
Foster research excellence; promote collaboration among research projects by seminars, retreats; provide general scientific direction for all cores.

Communication
Disseminate research findings and activities to public via media and events. Promote internal communication via newsletter and web.

Administrative Support
Provide administrative structure specific to the research such as purchasing scientific supplies, bidding for equipment, negotiating equipment contracts, and interface with the state system.

 



URL: http://kiddrc.kumc.edu/cored.html

Description

Objective:
Provide skilled and knowledgeable staff and state-of-the-art equipment to support imaging-based technologies necessary for conducting cutting-edge research related to intellectual and developmental disabilities.



Services

  • Molecular imaging including microarray and high throughput sequencing
  • Cell and tissue preparations for histological analyses
  • Image acquisition including multiple confocal microscopy platforms
  • Image analysis and processing including confocal stereology and morphometry
  • Image output including 2D and 3D renderings scientific and medical illustration

 

 



URL: http://kiddrc.kumc.edu/corec.html

Description

Objectives:

  • Consult with researchers on hypothesis development, research study design, sample size
  • Facilitate research related to intellectual and developmental disabilities by providing optimal data management and analysis resources.


Services

  • Research design
  • Data collection and management
  • Data analysis and interpretation, including complex statistical analyses and bioinformatics analysis of very large data sets
  • Education and training


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