UCLA Intellectual and Developmental Disabilities Research Center

URL: http://www.iddrc.ucla.edu/iddrc//cores.aspx

Description

The Animal Models Core will provide the following primary services: animal breeding and maintenance, genotyping, biohazardous materials usage and behavioral assessment.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

The discovery that the adolescent and even adult CNS possesses the potential to regenerate via multi-potent stem cells, has given rise to increasing interest in studying neural stem cells either to understand pathogenesis in neurodegenerative diseases in animal models or as potential therapeutic tools for degenerative diseases. The purpose of Cell Models core is to fulfill the need of incorporating new technology aimed at the study of the restoration of CNS function.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

The Cellular Imaging Core focuses on providing researchers with the ability to obtain high quality imaging data using state-of-the-art microscopy instruments. The Core also aims to provide information about imaging, image processing and cell/tissue processing for imaging.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

The Education Core is directed by Drs. Susan Bookheimer and James Waschek. It is designed to foster interactions and enrich the research and training environment of IDDRC faculty, trainees, and other personnel through annual retreats, minisymposia, invited speakers, and core-based technology workshops.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

Electrophysiological assessments will consist of experiments performed in brain slices, acutely isolated neurons or cultures providing a functional analysis of changes in neurons, local circuits and microcircuits induced primarily by genetic alterations in cellular, mouse or rat models.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

The Epigenetics Core provides genome-wide DNA methylation, histone modification, and chromatin immunoprecipitation (ChIP) services, along with targeted gene region analysis and validation, to support wide range of projects within the UCLA IDDRC.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

The Immunology core is intended to assist in both classical and new generation multicolor flow cytometry/FACS and in specialized immunohistochemical methods necessary to examine immune responses (microglia and subsequent astrocyte activation, invasion of macrophages and T helper subsets and other immune cells) in CNS pathology. This Core is intended to be applicable to both rodent models and in some cases human studies.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

The NeurogenomIcs/Bioinformatics core focuses on the application of genome-level analyses in neuroscientific investigation, most based on microarray related technologies, but also supporting a burgeoning use of next-generation sequencing-based approaches, such as RNA sequencing (RNA-seq) and ChIP-seq.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

IDDRC investigators are studying developmental and pathological processes that contribute to intellectual disabilities. The goal of the Stem Cells Core is to provide investigators with high quality cellular tools to enhance these studies and to contribute to the translational mission of the IDDRC.

URL: http://www.iddrc.ucla.edu/iddrc/cores.aspx

Description

The Translational Core for Human Phenotyping & Imaging provides two broad categories of services: 1) Pediatric neuroimaging services: behavioral desensitization protocols will be performed prior to scanning; MRI scan operation by personnel trained in pediatric imaging; experimental design and MRI pulse sequence protocol development consultation services, and imaging processing services; 2) Human phenotyping and protocol development: consultation for phenotyping, behavioral assessment of children with disabilities including pediatric assessment services and outcome measures for intervention, protocol development, and clinical trial consultation.