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Waisman Center

University of Wisconsin-Madison
1500 Highland Ave.
Madison, WI, 53705
608-263-5940

Scientific discovery is the mission of the Intellectual and Developmental Disability Research Center (IDDRC) -- discovering why child development goes awry, discovering ways to prevent intellectual and developmental disabilities, discovering treatments and interventions -- so that children and adults with disabilities can live, learn, work and enjoy their lives with their families and friends in their own communitites.

Established by Congress in 1963 as "centers of excellence" for research in intellectual and developmental disabilities, IDDRCs represent our nation's first sustained effort to prevent and treat intellectual and developmental disabilities through biomedical and behavioral research. Today, they represent the world's largest concentration of scientific expertise in the fields of intellectual and developmental disabilities. They form a network that fosters communication, innovation, and excellence in research.

The IDDRC at the Waisman Center involves 79 research projects headed by 46 faculty, representing 20 departments and 8 of the 12 schools or colleges of the University of Wisconsin-Madison. Major themes of the current IDDRC include: Nervous System Development and Pathogenesis; Intellectual and Developmental Disabilities Conditions; and Assessment, Interventions, and Therapeutics. Collectively, the activities of the Waisman Center IDDRC aim to stimulate innovative intellectual and developmental disabilities research, with a sharp focus on discovery, prevention, and treatment for intellectual and developmental disabilities conditions, and improvement of the quality of life of individuals with intellectual and developmental disabilities and their families.

Funding for the IDDRC from the Eunice Kennedy Shriver National Institute of Child Health and Human Development supports centralized, state-of-the-art research resources and facilities, which are shared by investigators with research projects at the Waisman Center.

CORE(s)

Core values are the internal compass of fundamental principles that drive the work of IDDRCs.

URL: http://www.waisman.wisc.edu/admin-core.htm

Description

The Administrative Core of the Waisman Center Intellectual & Developmental Disabilities Research Center (IDDRC) is the nucleus of the Waisman Center IDDRC. It provides the scientific, administrative, and fiscal leadership of the IDDRC, and supports investigators' needs for communications expertise and computing security. The core fosters multidisciplinary collaborations internally, and serves as the liaison between the IDDRC and the larger university and national and international organizations.

The overarching goal of the Administrative Core is to provide the environment in which science relevant to developmental disabilities and neurodevelopmental disorders flourishes and in which investigators can devote their maximum energy toward making scientific advances with the least administrative burden and the support of high quality, cost-effective core services.



Services

Scientific and Programmatic Leadership

  • Leadership in the development of core services
  • Recruitment and support of new investigators
  • Prioritization of core access
  • Liaison to other units and organizations
  • Promoting a cohesive, integrated research center

Biostatistics and Bioinformatics

  • Expertise and collaboration
  • Training in biostatistics and biomedical data science

Development of Public and Private Resources

  • Institutional commitment
  • Private funds and board of visitors

Research Administration

  • Dissemination of scientific information
  • Computing support and network security
  • Business services and human resources
  • Resource sharing

 

 



URL: http://www.waisman.wisc.edu/ImagingCore.htm

Description

The Brain Imaging Core is central to the integration of behavioral and biological research at the Waisman Center's IDDRC. Intellectual and developmental disabilities, whether resulting from environmental factors or genetic factors, involve a pathological alteration of brain structure and/or function. Examination of such alterations is critical to our understanding of the causal pathways from environmental or genetic processes to behavioral outcome and for the development of preventive or ameliorative interventions.



Services

The laboratory includes:

  • 3T MR scanner dedicated solely to research
  • Extensive visual, auditory and gustatory stimulation capabilities with online eye-tracking during MR scans
  • PET scanner
  • MicroPET scanner
  • Scanning simulation room with a mock scanner
  • Tandem accelerator to support the PET scanners
  • Psychophysiology facility
  • Dedicated computing facilities

 



URL: http://www.waisman.wisc.edu/CTCCore.htm

Description

The Clinical Translational Core provides support to investigators for some of the most challenging aspects of research involving human participants, including recruitment, diagnoses, assessment, computer programming and applications and advanced statistical analysis.



Services


Project Consultation

  • Participant screening, consenting, and session coordination
  • Coordination of research in Waisman Center Clinics or WECP
  • Assistance with IRB protocols as they pertain to CTC services
  • Coordination with UW Hospital Clinical Research Unit
  • Liaison with community hospitals/health centers

Psychological Testing

  • Assessment administration, scoring, interpretation
  • Intervention implementation
  • Clinical/diagnostic interviewing/screening
  • Assessment and intervention training
  • Protocol and project development
  • Psychological consultation
  • Graduate student psychological services supervision

Engineering

  • Computer programming
  • Database development and maintenance
  • Equipment and technical support consultation
  • Eye-tracking consultation

Participant and Research Registry Recruitment

  • Access to potential research participants through several research registries
  • Consultation and recruitment planning
  • Diversity and Community outreach
  • Participant recruitment in the Waisman Center Clinics or Waisman Early Childhood Program

Private Testing Rooms

  • A large testing room with a sink, small observation room, and audio and video camera equipment
  • Individual sound attenuated booths
  • Two adjoined small testing rooms with adult-sized tables and chairs, and equipment to allow for monitoring and recording a session from one room to the other
  • Two Tobii T60XL eye tracker suites, with E-Prime, Tobii Studio, and SMART-T stimulus software.

Data Analysis

  • Statistical Consultation

Psychological Assessment Kit Library

  • Medical
  • Skin biopsies

Datebase Hosting

  • Waisman Biomanufacturing
  • Access to Marshfield Clinic's Personalized Medicine Research Project (PMRP)

 

 



URL: http://www.waisman.wisc.edu/cores-idd-models.htm

Description

The Intellectual and Developmental Disabilities (IDD) Models Core in the Waisman Center provides a number of resources to investigators within our center as well as to other campus investigators. First, the core provides mouse models of human conditions, along with behavioral testing capabilities to characterize these models and test new therapies. Second, we provide state-of-the-art stem cell technologies to support creation of induced pluripotent stem cell lines for IDD conditions as well as specialized genome editing services. Finally, we provide high quality, cost effective, microscopy technology and expertise for characterization of both stem cell and mouse models of IDD conditions.



Services

Cellular Imaging and Analysis Lab

  • Fluorescence/Brightfield and Confocal Microscopy
  • Fluorescence Quantitation
  • Cellular Imaging and Analysis Instrumentation
  • Consultation, Support and Training

Induced Pluripotent Stem Cells (iPSC) Services

  • iPSC cloning, including mycoplasma testing, marker immunofluorescence, and WiCell characterization (for University of Wisconsin researchers)
  • Gene mutation correction/induction
  • Endogenous site reporter insertion
  • Safe harbor site reporter insertion
  • Lineage-tracing dual insertion
  • Custom gene editing projects

Rodent Models

  • Reproductive services
  • Transfers & shipments
  • Behavioral testing
  • Transgenic/knockout services
  • Technical consultation

 



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