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University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)

University of Iowa Carver College of Medicine
100 Hawkins Drive
Iowa City, IA, 52242
319-678-3054

Our mission is to create an exceptional environment to conduct research across the lifespan—from conception to adulthood—which fully integrates basic and clinical science, and focuses on the diagnosis, prevention, treatment and amelioration of intellectual and developmental disabilities by addressing both intrinsic (genetic) and extrinsic (environmental/experiential) risk factors.

The Hawk-IDDRC includes four components:

1) The Hawk-IDDRC Research Project will examine the interaction of genetic or environmental risks in young children with developmental disabilities, including autism, and integrate services from all four Research Cores.

2) Four Research Cores facilitate many different types of research at the IDDRC, including:

  • an Administrative Core (AC) that provides leadership to ensure thorough and cost-effective research of intellectual and developmental disabilities, while inspiring collaboration and innovation.
  • Clinical Translational Core (CTC), which applies basic science discoveries into clinical settings by streamlining patient recruitment, analyzing data and implementing clinical trials for the development of treatments that can be employed across the lifespan.
  • Developmental Genomics/Epigenetics Core (DGC), which uses medical sequencing to uncover variations in the genes and how outside factors affect them, and the association of these with IDD.
  • Neurocircuitry and Behavior Core (NBC), which assesses both animal and human development, function and behavior.

These four cores provide cutting-edge resources and expertise to researchers in the Center, with the ultimate goal of developing effective interventions to assist individuals and families with IDD.

3) A Dissemination and Communication Plan ensures Hawk-IDDRC research is effectively communicated to the scientific community, educators, policy makers, government officials, and the public, in an engaging and timely manner; and

4) An Educational Program, involving scientists, trainees, the public, and IDD-affected families, and features monthly seminars, mentoring of young and talented investigators focused on IDD research, and an educational program aimed at the public and IDD community.

CORE(s)

Core values are the internal compass of fundamental principles that drive the work of IDDRCs.

URL: https://iddrc.uiowa.edu/research-cores/administrative-core

Description

The Administrative Core (AC) provides leadership to ensure thorough and cost-effective research of intellectual and developmental disabilities, while inspiring collaboration and innovation.



Services

  • New project research consultation
    • Basic science
    • Clinical
  • Biostatistics support
  • Pilot grant application
  • Research dissemination support (social media, press release, UCEDD exposure, etc.)
  • Seminar and Workshops


URL: https://iddrc.uiowa.edu/overview-hawk-iddrc/research-cores/clinical-translational-core

Description

The Clinical Translational Core (CTC) applies basic science discoveries into clinical settings by streamlining patient recruitment, analyzing data and implementing clinical trials for the development of treatments that can be employed across the lifespan.



Services

  • Patient recruitment and clinical evaluation
    • Global Pregnancy Collaboration (CoLab)
    • Women’s Health Center (WHC)
    • Center for Disabilities and Development evaluation
    • Autism Center evaluation
    • Division of Child and Community Health/ Child Health Specialties Clinic
    • Neurodevelopmental Registry
    • Intellectual Disability-Mental Illness Program
  • Biobanking and bioinformatics services
    • Women’s Health Tissue Repository (WHTR) and WHTR-related cohorts
    • Iowa Newborn Screening Program
    • SPARK (Simons Foundation Powering Autism Research for Knowledge)
    • Clinical Datamart / Data Acquisition Technologies
    • Maternal Fetal Tissue Bank
    • REDCap and e-consenting
    • ICTS Biomedical Informatics TriNetX training
    • Environmental Health Sciences Research Center
  • Clinical trials and drug manufacturing services
    • The Clinical Trials and Statistical & Data Management Center
    • ICTS Clinical Research Unit (CRU), including support for clinical trials
    • Investigational Drug Service (IDS)
    • High Throughput Screening Facility (UIHTS)


URL: https://iddrc.uiowa.edu/research-cores/developmental-genomics-epigenetics-core

Description

The Developmental Genomics/Epigenetics Core (DGC) uses medical sequencing to uncover variations in the genes and how outside factors affect them, and the association of these with IDD.



Services

  • Genomics
    • Chromosomal microarray analysis (CMA)
    • Microarray SNP genotyping
    • Exome sequencing (ES)
    • Genome sequencing (GS)
    • DNA methylation analysis
    • Transcriptome sequencing (RNA-Seq)
    • Single-cell and single-nucleus gene expression
  • Bioinformatics
    • QC of FASTQ files using FASTQC
    • Alignment of sequencing reads to the appropriate reference genome using BWA
    • Variant calling using GATK
    • Differential expression pipelines using STAR, RUVseq, and edgeR
    • Single-cell pipelines using Seurat
    • Differential methylation analysis


URL: https://iddrc.uiowa.edu/research-cores/neurocircuitry-and-behavior-core

Description

A Neurocircuitry and Behavior Core (NBC) assesses both animal and human development, function and behavior.



Services

  • Neuroimaging
    • Human Neuroimaging
      • MRI
      • PET
      • CT
      • Near-infrared Spectroscopy (NIRS)
      • Image Acquisition and Protocol Development
      • Post-acquisition Processing
    • Animal neuroimaging
      • MRI
      • PET
      • CT
      • SPECT
      • Image Analysis
    • Bioinformatics consultation
  • Neural Circuits and Behavior
    • Human Assessments
      • Infant Sleep Assessment
      • NIH Toolbox
      • Other cognitive tasks in consultation with staff
      • Autism Diagnostic Observation Schedule (ADOS) Assessment
      • Task based fMRI paradigms
      • Non-invasive Brain Stimulation
  • Animal Assessments
    • Cognitive Assessments
    • Novel Motor Assessments
    • Animal Sleep Assessments
    • Other behavioral assessments
    • Animal Housing
    • Access to LaVision Light Sheet Microscope
    • Access to Multiphoton Microscopes for in vivo and in vitro two photon imaging
    • Bioinformatics consultation