PHARM - Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth

2014

L. Eugene Arnold
[email protected]
614-685-6708

Background. Neuroimaging measures of behavioral and emotional dysregulation can yield biomarkers denoting developmental trajectories of psychiatric pathology in youth. We aimed to identify functional abnormalities in emotion regulation (ER) neural circuitry associated with different behavioral and emotional dysregulation trajectories using latent class growth analysis (LCGA) and neuroimaging. Method. A total of 61 youth (917 years) from the Longitudinal Assessment of Manic Symptoms study, and 24 healthy control youth, completed an emotional face n-back ER task during scanning. LCGA was performed on 12 biannual reports completed over 5 years of the Parent General Behavior Inventory 10-Item Mania Scale (PGBI-10M), a parental report of the childs difficulty regulating positive mood and energy. Results. There were two latent classes of PGBI-10M trajectories: high and decreasing (HighD; n= 22) and low and decreasing (LowD; n= 39) course of behavioral and emotional dysregulation over the 12

amygdala, dysregulation, prefrontal, emotional, behavioral

Peer-reviewed publications in scholarly journals Published/In Press

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