Population Specific GSTM1 Copy Number Variation

2009

Center Info Desk AAA
[email protected]
312-413-8888

Huang, R.S., Chen, P., Wisel, S., Duan, S., Zhang, W., Cook, E.H., Das, S., Cox, N.J., Dolan, M.E. (2009). Population Specific GSTM1 Copy Number Variation. Human Molecular Genetics,18, 366?372. - As one of the major glutathione conjugation enzymes, GSTM1 detoxifies a number of drugs and xenobiotics. Its expression and activity have been shown to correlate both with cancer risks and drug resistance. Through a genome-wide association study, we identified a significant association between HapMap SNP rs366631 and GSTM1 expression. In this study, utilizing lymphoblastoid cell lines derived from International HapMap Consortium CEU and YRI populations, we designed and performed site-specific genotyping assays for both rs366631 and a highly homologous GSTM1 upstream site.

Peer-reviewed publications in scholarly journals Published/In Press

N/A