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This article examines Gene Environment (G X E) interactions in two comorbid developmental disorders?
reading disability (RD) and attention-deficit/hyperactivity disorder (ADHD)?as a window on broader issues
on G X E interactions in developmental psychology. The authors first briefly review types of G X E
interactions, methods for detecting them, and challenges researchers confront in interpreting such interactions.
They then review previous evidence for G X E interactions in RD and ADHD, the directions of which are
opposite to each other: bioecological for RD and diathesis stress for ADHD. Given these results, the authors
formulate and test predictions about G X E interactions that would be expected at the favorable end of each
symptom dimension (e.g., above-average reading or attention). Consistent with their prediction, the authors
found initial evidence for a resilience interaction for above-average reading: higher heritability in the presence
of lower parental education. However, they did not find a GE interaction at the favorable end of the ADHD
symptom dimension. The authors conclude with implications for future research.