Active Targeted Macrophage-Mediated Delivery of Catalase to Affected Brain Regions in Models of Parkinson's Disease

2012

Anna Dunaevsky
[email protected]
402-559-1071

We previously demonstrated that monocyte-macrophage based drug delivery can be applied to a spectrum of infectious, neoplastic, and degenerative disorders. In particular, bone marrow-derived macrophages (BMM) loaded with nano formulated catalase, ?nanozyme?, were shown to attenuate neuro inflammation and nigrostriatal degeneration in rodent models of Parkinson?s disease (PD). Nonetheless, the pharmacokinetics and biodistribution of BMMincorporated nanozyme has not been explored. To this end, we now demonstrate that BMM, serving as a ?depot? for nanozyme, increased area under the curve(AUC), half-life, and mean residence time in blood circulation of the protein when compared to the nanozyme administered alone. Accordingly, bioavailability of the nanozyme for the brain, spleen, kidney, and liver was substantially increased. Importantly, nanozyme-loaded BMM targeted diseased sites and improved transport across the blood brain barrier.

Drug biodistribution, Cell-mediated drug delivery, Nanozyme, Parkinson?s disease, Pharmacokinetics

Peer-reviewed publications in scholarly journals Published/In Press

Professionals, Students

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