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Product

Article: Systematic review and meta-analysis of pharmacological treatment of the symptoms of attention-deficit/hyperactivity disorder in children with pervasive developmental disorders

Center:

CT-A. J. Pappanikou Center for Developmental Disabilities, UCEDD/LEND

Fiscal Year:

2014

Contact Information:

Mary Beth Bruder
[email protected]
860-679-1500

Product Description:

Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects metaanalysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = .67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.

Keyword(s):

Autism, Pervasive Developmental Disorder, Attention deficit/hyperactivity disorder, Methylphenidate, Meta-analysis

Product/Publication Type(s):

Peer-reviewed publications in scholarly journals Published/In Press

Target Audience:

Professionals, Students

Alternative Format:

Electronic (disc, CD, 508 compliant web posting)

To Obtain Copies (URL or Email):

http://link.springer.com/article/10.1007/s10803-013-1793-z

COVID-19 Related Data:

N/A